Mito and Madara

Madara really liked Mito he was jealous that Hashirama married her. When he find out about Nayuki's sharingan he do everything to take her away from Hashirama. He became guardian to Nayuki, he almost haved a daughter from Mito. Mito know it that he loves her and wouldnt let Nayuki get hurt. But that was only a mask after few years he started to show his hated to Nayuki because she was Hashirama's daughter, he tried to kill her but Izuna didnt let him. Izuna loved her more then anything.

Hashirama Senju Died

During his time as Hokage, Hashirama came into possession of a scroll filled with, among other skills, various kinjutsu, which he sealed away in order to keep the techniques within it a secret. He also defeated Kakuzu, who had been sent to assassinate him by Takigakure. At some point, Hashirama gained control of several tailed beasts. He spread these beasts to other, newly-formed villages in an attempt to maintain peace and equalise the powers between the nations, but it did not stop the outbreak of the First Shinobi World War. Thinking about the future of Konoha, he and his younger brother, Tobirama Senju, trained the young Hiruzen Sarutobi. Hashirama died shortly after the founding of Konoha in one of the many wars that were raging during this revolutionary era, but not before passing on the title of Hokage to Tobirama. 

Mito Uzumaki Died

Towards the final years of her life, it was decided that a new host for Kurama would have to be found. She wanted to give it to Nayuki but she had already a demon. Kushina Uzumaki, one of Mito's clansmen, was then selected for the role due to her special chakra. Terrified by the idea of having been taken from her home to become a jinchūriki, Mito comforted her, and told Kushina that in order to counter the fox's hatred, she needed to fill herself with love. Some time after this, the beast was presumably extracted from within Mito and sealed into Kushina.

History

Nayuki Uchiha is member of Team 7 and Akatsuki. She got the ten tail wolf demon in her. She can copy any jutsu by a kiss. She become the 6 Hokage. Her father is Hashirama Senju ( The 1st Hokage) and her mother is Mito Uzumaki.
When she was born no one knows about her copy jutsu. One day she played with Izuna and he kiss her friendly then she got the sharingan. The Uzumaki clan tried to stay a secret but Madara found about it and took her from the Uzumaki clan and made her Uchiha.

Me before Mito die

Mito Uzumaki

Mito Uzumaki was a kunoichi who originated from Uzushiogakure's Uzumaki clan. She later married Konohagakure's Hashirama Senju. She was also the first jinchūriki of Kurama, the Nine-Tails.

 Hashirama Senju ( The 1st Hokage)

 Hashirama Senju renowned as the God of Shinobi, was a legendary ninja who hailed from the Senju clan that together with the Uchiha clan, established the first shinobi village: Konohagakure. He would later go on to become the village's First Hokage